Data Mapper tool
Map your own data in interactive plots
Odorant receptors
All human ORs and major model organisms
Structure models
Inactive-/active state GPCRs and physiological ligand complexes
Structure analysis resource
Structure comparison tool and similarity trees.
Structure similarity search
Search all of GPCRdb’s structures and models
Ligand search
Find ligands by name, database identifier, similarity or substructure
GPCRdb
G protein-coupled receptors (GPCRs) are cell-surface receptors mediating the responses of 2/3rds of human hormones1 and 1/3rd of
drugs2.
Each GPCR can bind several transducers, G proteins, GPCR kinases (GRKs) and arrestins
leading to distinct intracellular signaling networks and functional outcomes.
Data
- 804 Human proteins
- 42,026 Species orthologs
- 3,013 Generic residues
- 1,610 GPCR structures
- 857 Refined structures
- 1,601 GPCR structure models
- 625 Physiological ligand-GPCR structure models
- 968 Drugs
- 175 Drug targets
- 405 Disease indications
- 219,361 Ligands
- 527 Physiological ligands
- 494,390 Ligand bioactivities
- 36,138 Ligand site mutations
- 63,300 Ligand interactions
Publications
GPCRdb in 2025: adding odorant receptors, data mapper, structure similarity search and models of physiological ligand complexes.
Nucleic Acids Research, 2024
An online GPCR structure analysis platform.
Nature Structural & Molecular Biology, 2021
Trends in GPCR drug discovery: new agents, targets and indications.
Nature Reviews Drug Discovery, 2017
Generic GPCR residue numbers - aligning topology maps while minding the gaps.
Trends in pharmacological sciences, 2015