Data Mapper tool
Map your own data in interactive plots
Odorant receptors
All human ORs and major model organisms
Structure models
Inactive-/active state GPCRs and physiological ligand complexes
Structure analysis resource
Structure comparison tool and similarity trees.
Structure similarity search
Search all of GPCRdb’s structures and models
Ligand search
Find ligands by name, database identifier, similarity or substructure
GPCRdb
G protein-coupled receptors (GPCRs) are cell-surface receptors mediating the responses of 2/3rds of human hormones1 and 1/3rd of
drugs2.
Each GPCR can bind several transducers, G proteins, GPCR kinases (GRKs) and arrestins
leading to distinct intracellular signaling networks and functional outcomes.
Data
- 805 Human proteins
- 41,688 Species orthologs
- 69,580 Genetic variants
- 968 Drugs
- 175 Drug targets
- 405 Disease indications
- 219,293 Ligands
- 527 Endogenous ligands
- 493,216 Ligand bioactivities
- 36,136 Ligand site mutations
- 52,636 Ligand interactions
- 1,296 GPCR structures
- 1,601 GPCR structure models
- 634 GPCR-ligand structure models
- 3,011 Generic residues
- 743 Refined structures
Latest release
Nov. 6, 2024- New
- Odorant receptors (human + model organisms)
- Data Mapper (map own data onto GPCR plots)
- Physiological ligand-GPCR complex models (AF2-Multimer and RoseTTAFold)
- Structure Similarity Search (Foldseek)
- Updated
- Ligand search tool (by name, database ID, structure)
- Inactive-/active-state GPCR models (AF2 and AF2-Multistate)
- Minor bug and performance fixes
All releases
Publications
GPCRdb in 2023: State-specific structure models using AlphaFold2 and expansion of ligand resources.
Nucleic Acids Research, 2023
An online GPCR structure analysis platform.
Nature Structural & Molecular Biology, 2021
Trends in GPCR drug discovery: new agents, targets and indications.
Nature Reviews Drug Discovery, 2017
Generic GPCR residue numbers - aligning topology maps while minding the gaps.
Trends in pharmacological sciences, 2015